Developing novel C-4 analogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine site

Developing novel C-4 analogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine site Pyrrole-Based Antitubulin Agents: Two Distinct Binding Modalities Are Predicted for C-2 Analogues in the Colchicine Site Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site Synthesis, biological evaluation and molecular modeling of imidazo[1,2-a]pyridine derivatives as potent antitubulin agents Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent Synthesis and tubulin binding of novel C-10 analogs of colchicine Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents