Novel Potentiators for Vancomycin in the Treatment of Biofilm-Related MRSA Infections via a Mix and Match Approach

ACS Medicinal Chemistry Letters
2017.0

Abstract

A library of 52 hamamelitannin analogues was synthesized and investigated for its ability to potentiate the effect of vancomycin toward Staphylococcus aureus biofilms. Several compounds were found to effectively increase the susceptibility of staphylococcal biofilms toward this glycopeptide. The most active analogue identified in this study showed an EC50 value of 0.26 μM.

Knowledge Graph

Similar Paper

Novel Potentiators for Vancomycin in the Treatment of Biofilm-Related MRSA Infections via a Mix and Match Approach
ACS Medicinal Chemistry Letters 2017.0
Identification of potent and broad-Spectrum antibiotics from SAR studies of a synthetic vancomycin analogue
Bioorganic & Medicinal Chemistry Letters 2003.0
Novel synthetic organic compounds inspired from antifeedant marine alkaloids as potent bacterial biofilm inhibitors
Bioorganic Chemistry 2015.0
Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus
Bioorganic & Medicinal Chemistry Letters 2006.0
In Vitro Activities of Telavancin and Vancomycin against Biofilm-Producing Staphylococcus aureus , S . epidermidis , and Enterococcus faecalis Strains
Antimicrobial Agents and Chemotherapy 2009.0
Cyclic homopentapeptides 1. Analogs of tuberactinomycins and capreomycin with activity against vancomycin-resistant enterococci and Pasteurella
Bioorganic & Medicinal Chemistry Letters 1997.0
Parallel synthesis of a bis-triazoles library as psammaplin A analogues: A new wave of antibiofilm compounds?
Bioorganic & Medicinal Chemistry Letters 2019.0
Membrane Active Vancomycin Analogues: A Strategy to Combat Bacterial Resistance
Journal of Medicinal Chemistry 2014.0
Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis
RSC Medicinal Chemistry 2019.0
Towards smart biocide-free anti-biofilm strategies: Click-based synthesis of cinnamide analogues as anti-biofilm compounds against marine bacteria
Bioorganic & Medicinal Chemistry Letters 2018.0