Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6)

Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6) Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1′H-spiro[chromene-2,4′-piperidine]-1′-carboxamides as TRPM8 antagonists Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity