Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity

Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity Discovery of DS34942424: An orally potent analgesic without mu opioid receptor agonist activity Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain 3-(1-Indolinyl)benzylamines: a new class of analgesic agents Discovery, structure–activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists 5,11-Dimethyl-2,9-bis(phenylacetyl)-5,11-diazatetracyclo[6.2.2.02,7.04,9]dodecane, a potent, novel analgesic Synthesis and analgesic profile of conformationally constrained N-acylhydrazone analogues: Discovery of novel N-arylideneamino quinazolin-4(3H)-one compounds derived from natural safrole