Alkylsulfanyl analogs as potent α 2 δ ligands

Alkylsulfanyl analogs as potent α 2 δ ligands A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity Neuropathic pain-alleviating effects of pyrazole-conjugated arylsulfonamides as 5-HT6 receptor antagonists Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives Part 3: Design and synthesis of proline-derived α2δ ligands (R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation Synthesis and pharmacological evaluation of N-phenyl-acetamide sulfonamides designed as novel non-hepatotoxic analgesic candidates