Evaluation of neomycin analogues for HIV-1 RRE RNA recognition identifies enhanced activity simplified neamine analogues

Evaluation of neomycin analogues for HIV-1 RRE RNA recognition identifies enhanced activity simplified neamine analogues Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA–protein interactions derived from HIV-1 activators Binding of dimeric aminoglycosides to the HIV-1 rev responsive element (RRE) RNA construct Neamine dimers targeting the HIV-1 TAR RNA Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1 Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA Study of aminoglycoside–nucleic acid interactions by an HPLC method Synthesis of (+),(−)-neamine and their positional isomers as potential antibiotics