Discovery of DS34942424: An orally potent analgesic without mu opioid receptor agonist activity

Discovery of DS34942424: An orally potent analgesic without mu opioid receptor agonist activity Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery ofN,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747) Discovery, Structure–Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic Synthesis and analgesic activity of some spiro[dibenz[b,f]oxepin-10,4'-piperidine] derivatives 5,11-Dimethyl-2,9-bis(phenylacetyl)-5,11-diazatetracyclo[6.2.2.02,7.04,9]dodecane, a potent, novel analgesic 3-(1-Indolinyl)benzylamines: a new class of analgesic agents Unique spirocyclopiperazinium salt III: Further investigation of monospirocyclopiperazinium (MSPZ) salts as potential analgesics