An effective method to produce 7-epitaxol from taxol in HCO3–

Bioorganic & Medicinal Chemistry Letters
2020.0

Abstract

It is known that 7-epitaxol has much stronger cytotoxicity than taxol does. However, the content of 7-epitaxol in yew is much less than taxol, which makes it more costly to obtain. We describe here a method to effectively convert taxol to 7-epitaxol. The key condition for reaction needs NaHCO<sub>3</sub> in solvent acetonitrile (ACN). The conversion rate can be over 82%.

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