Design and synthesis of new taxol-containing aminophosphates as protaxols

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

Taxol-containing aminophosphates 5-7 were synthesized as protaxols by a "oneflask" method; the intrinsic zwitterionic character increases their solubility to about six times higher than that of taxol in a phosphate buffer solution.

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