From the epigeal part of Senecio vernalis Waldst. et Kit. (family Asteraceae) collected in the Karelian district in the period of full flowering by extraction with 5% sulfuric acid solution in the presence of zinc dust and subsequent purification, we have obtained the total alkaloids in an amount of 0.2%. TLC on KSK silica gel (mobile phase, methanol) gave two spots revealed by Dragendorff's reagent: with Rf 0.20 and 0.50. The combined alkaloids were separated into their components by column chromatography on silica gel L 100/160. Two bases were obtained, and the melting points of mixtures of the alkaloids isolated with authentic samples of platiphylline and seneciphylline, respectively, showed no depression. By chromatographing the combined alkaloids in a fixed layer of silica gel and by colorimetry we determined total platiphylline and seneciphylline contents, finding that platiphylline made up 70% and seneciphylline 29.9% of the combined alkaloids. We are the first to have isolated the alkaloids platiphylline and seneciphylline from the epigeal part of Senecio vernalis.