Previous chemical investigations (1,2) of Zanthoxylum gillettii Waterm. (syn. Fagara marrophylla (Planch ex. Oliv.) Engl., Rutaceae) describe the isolation of the furoquinoline alkaloid, skimmianine, the cinnamic acid amide, fagaramide, and the benzo (c) phenanthridine alkaloids, chelerythrine, dihydrochelerythrine, and nitidine. The present work describes the identification of arnottianamide, N-isobutyl-(2E,4E)-dodecadienamide, lupeol, N-isobutyl-2,4,8,10,12-tetradecapentaenamide (γ-sanshotil), and sitosterol as new constituents. Arnottianamide isolated showed the same spectral data as a sample obtained on chemical modification of chelerythrine chloride. This result represents a first detailed report of the identification of both aliphatic and aromatic amides in this plant. Sitosterol, lupeol, γ-sanshotil, and fagaramide are known constituents of many Rutaceae species. N-isobutyl- (2E,4E)-dodecadienamide is a known constituent of Piper peepuloides (5) and has been found in trace amounts as a component of pellitorine obtained as the insecticidal fraction of Anacyclus pyrethrum roots (6). This is, however, its first report as a constituent of a Rutaceae species. Arnottianamide, now being reported for the first time in an African Rutaceae, has also been found in small amounts in Fagara arbrescens, Zanthoxylum arnottianum, Zanthoxylum bungeanum, and Zanthoxylum cuspidatum (7). Its facile preparation from chelerythrine chloride strongly supports the supposition (3) that it may have been formed through a similar Baeyer-Villiger-like oxidation process in vivo. Its Occurrence with chelerythrine previously isolated from this plant bears some biogenetic significance.