The isolation of two new tyramine derivatives, acidissiminol [1] and acidissiminin epoxide [2], and N-benzoyltyramine [3] from the fruits of Limonia acidissima is described. Structures were elucidated by uv, ir, nmr, eims, and/or cims measurements. The comparison of spectral data of 1 with those of an authentic sample prepared from acidissiminin [4], previously isolated from the same plant, conclusively established the structure of 1 as benzamide-N-{p-[(3,7-dimethyl-4-hydroxy-2,6-octadienyl)oxy]phenethyl}. Spin decoupling experiments on 2 and structure elucidation of degraded material 5 obtained through hydrolytic cleavage of 2, established the structure of acidissiminin epoxide [2] as benzamide-N-(p-{(3,7-dimethyl-6,7-epoxy-4-octadecanoyloxy-2-octenyl)oxy]phenethyl}. The family Rutaceae is known for economically important secondary metabolites (1). Limonia acidissima L. is well known for its medicinal properties (2). Several coumarins, a triterpene, steroids, limonoids, benzoquinone and alkaloids (3-7), acids (8), and a tyramine derivative, acidissiminin (9), have already been reported from different parts of this plant. The occurrence of N-benzoyltyramine and its derivatives was previously reported from a few species of Rutaceae (10-15) and from one species of Lauraceae (16). We now report the structure elucidation of two new tyramine derivatives, acidissiminol [1] and acidissiminin epoxide [2], along with the isolation of N-benzoyltyramine [3] from the fruits of L. acidissima.