The isolation and characterization of fourteen leaf alkaloids of Lunasia umara Blanco are described. A number of chemical and pharmacological studies of Lunasia alkaloids have been recorded since the initial observations of Lewin and Boorsma, but the structures of these compounds have been unknown until recently. Both leaves and bark of trees of this genus of the Rutaceae contain "water-soluble" alkaloids which are quaternary salts, and the organic bases include representatives of five classes of compounds. The following sections summarize what is known about the occurrence and structure of each of the alkaloids, and the Experimental section contains data relating to the isolation and characterization of the leaf bases of Lunasia amara Blanco of Philippine origin. With one exception (lunamaridine), all of the previously known bases have been found, together with a number of new ones. Table I contains formulas, melting points and yields of the leaf bases.