<jats:title>ABSTRACT</jats:title> <jats:p> The genome sequence of <jats:named-content content-type="genus-species">Streptomyces rimosus</jats:named-content> R6-500, an industrially improved strain which produces high titers of the important antibiotic oxytetracycline, is reported, as well as the genome sequences of two derivatives arising due to the genetic instability of the strain.