Two Novel Norditerpenoid Alkaloids from Delphinium staphisagria

Journal of Natural Products
1990.0

Abstract

Two novel norditerpenoid alkaloids, staphisadrine [1] and staphisadrinine [2], have been isolated from Delphinium staphisagria. Structures 1 and 2 were determined from physical and spectroscopic data, including DEPT and nOe difference experiments. Staphisadrine [1] is the first example of an aconitine-type alkaloid bearing a formyl group on C-4. Staphisadrinine [2] is the first norditerpenoid alkaloid that possesses a carbonyl function on C-16. Two known norditerpenoid alkaloids, pyrodelphinine [3] and 14-acetyl-1-epi-neoline [4], were also isolated and have not been previously reported as natural products.

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