Studies on the Constituents of Broussonetia Species. V. Two New Pyrrolidine Alkaloids, Broussonetines K and L, as Inhibitors of Glycosidase, from Broussonetia kazinoki SIEB.

Chemical and Pharmaceutical Bulletin
1999.0

Abstract

Two new pyrrolidine alkaloids, broussonetines K and L, were isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae). Broussonetines K and L were formulated as (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(1R)-1-hydroxy-10-oxo-13-(β-p-glucopyranosyloxy) tridecyll pyrrolidine (1) and (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(1R)-1-hydroxy-9-oxo-13-(β-D-glucopyranosyloxy) tridecyll pyrrolidine (2), respectively, by spectroscopic and chemical methods. 1 and 2 inhibited β-glucosidase, β-galactosidase and β-mannosidase.

DOI： 10.1248/CPB.47.472

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