Studies on the Constituents of Broussonetia Species. I. Two New Pyrrolidine Alkaloids, Broussonetines C and D, as .BETA.-Galactosidase and .BETA.-Mannosidase Inhibitors from Broussonetia kazinoki SIEB.

Chemical and Pharmaceutical Bulletin
1997.0

Abstract

Two new pyrrolidine alkaloids called broussonetines C and D were isolated from the branch of Broussonetia kazinoki SIEB. (Moraceae). Broussonetines C and D were formulated as (2R,3R,4R,5R)-2-hydroxymethyl-3,4- dihydroxy-5-(10-oxo-13-hydroxytridecyl)pyrrolidine (1) and (2R,3R,4R,5R)-2- hydroxymethyl-3,4-dihydroxy-5-(9-oxo-13-hydroxytridecyl)pyrrolidine (2), respectively, by spectroscopic and chemical methods. 1 and 2 showed an inhibition to β-galactosidase and β-mannosidase.

DOI： 10.1248/cpb.45.505

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