Studies on the Constituents of Broussonetia Species. III. Two New Pyrrolidine Alkaloids, Broussonetia G and H, as Inhibitors of Glycosidase, from Broussonetia kazinoki SIEB.

Chemical and Pharmaceutical Bulletin
1998.0

Abstract

Two new pyrrolidine alkaloids, broussonetines G and H, were isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae). Broussonetines G and H were formulated as 2 beta-hydroxymethyl-3 alpha, 4 beta-dihydroxy-5 alpha-(1-hydroxy- 6:10;10:13-diepoxytridecyl)-pyrrolidine (1) and 2 beta-hydroxymethyl-3 alpha, 4 beta-dihydroxy-5 alpha-(1-hydroxy- 5:9;9:13-diepoxytridecyl)-pyrrolidine (2), respectively, by spectroscopic methods. 1 and 2 inhibited beta-glucosidase, beta-galactosidase and beta-mannosidase.

DOI： 10.1248/cpb.46.1048

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