<jats:p>Two new benzylisoquinoline alkaloids of the papaverine type, setigerine (racemic α-methoxypapaverine, <jats:bold>1b</jats:bold>) and setigeridine (<jats:bold>1c</jats:bold>), were isolated from <jats:italic>Papaver setigerum</jats:italic> DC. as the minor constituents. Their structures were established by spectral data and X-ray crystallographic analysis. Papaverine (<jats:bold>1a</jats:bold>) was isolated as the major alkaloid of the plant (0.05 wt.%) besides of less amounts of morphine, codeine and rhoeadine. In a low yield, protopine, cryptopine, thebaine, rhoeagenine, and <jats:italic>N</jats:italic>-methylthebainium (as iodide) were obtained and small quantities of laudanosine, stylopine, isoboldine, scoulerine, papaverrubine A, B, C, D and E, coptisine, corytuberine, and magnoflorine were identified by thin layer chromatography.