Four alkaloids, 5'-des-O-methylharringtonine, 3'S-hydroxy-5'-des-O-methylharringtonine, 5'-des-O-methylhomoharringtonine and 5'-des-O-metbylisohaningtonine, were isolated from the leaves and stems of C. harringtonia var, drupacea, Their structures were established by H-1 and C-13 NMR spectroscopic studies, chemical conversions to known alkaloids and applying the advanced Mosher's method for the secondary alcohol moiety. Copyright (C) 1996 Elsevier Science Ltd