Three oxygenated cephalotaxine ester-type alkaloids, 11R-hydroxyhomodeoxyharringtonine (1), 11â-hydroxyhomodeoxyharringtonine (2) and 11â-hydroxydeoxyharringtonine (3) were isolated from Cephalotaxus harringtonia var. drupacea. Their structures were established by spectroscopic methods including 2D NMR and CD spectra, and their antileukemic activity was evaluated using P-388 leukemia cells.