A new putrescine bisamide derivative named cucullamide (1) was isolated from the leaves of Amoora cucullata, together with five known natural products, dasyclamide (2), ent-2beta-hydroxymanool (3), chrysin (4), apigenin (5), and kaempferol-3-O-beta-D-glucopyranoside (6). The structure of the new isolated compound was elucidated on the basis of 1D and 2D NMR as well as high resolution-electrospray ionization (HR-ESI)-MS spectroscopic analysis.