Cytochrome P450 2D6 inhibitory constituents of Lunasia amara

Phytochemistry Letters
2011.0

Abstract

From a MeOH extract of Lunasia amara, which showed the cytochrome P450 2D6 (CYP2D6) inhibition, 14 acridone alkaloids including two new alkaloids [5-hydoroxygraveoline (1) and 8-methoxyifflaiamine (2)] were identified. Among the 14 acridone alkaloids, 5-hydoroxygraveoline (1) and lunamarine (3) showed moderate inhibition selective for CYP2D6, with IC50 values of 4.7 mu M and 1.8 mu M, respectively. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.phytol.2010.10.006

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