A new alkaloid named nobilisine (5a-hydroxy-3a, Sa-epi-masan-7-one) 111 was isolated from Clivia nobilis cultivated in Egypt. Its structure was established from spectroscopic data utilizing mass spectral and two-dimensional 'H-nmr methods. Clivatine and lycorine were also isolated and identified as congeners of 1 in C. nobilis.