A new dimeric indole alkaloid of the 1-norpleiomutine type, (+)-kopsoffine, has been isolated from the roots of Kopsia officinalis. The proposed structure was confirmed by partial synthesis. The dihydroeburnamenine moiety of (+)-kopsoffine was found to be the optical antipode of that present in (-)-pleiomutine. Detailed 1H-nmr data of (-)-isoeburnamine, (+)-eburnamine, and (-)-eburnamonine are also presented. © 1984, American Chemical Society. All rights reserved.