Chromatography of an ethanolic extract of Pycrarrhena manillensis over silica gel afforded phaeanthine-2′α-N-oxide (1) and pycmanilline (2) which were characterized as new bisbenzylisoquinoline alkaloids by a consideration of physicochemical data and the utilization of simple chemical reactions. Phaeathine-2′α-N-oxide (1) was reduced to phaeanthine (3) while pycmanilline (2), a secobisbenzyliso-quinoline alkaloid, was prepared via oxidation of phaeanthine (3). © 1987.