Semisynthetic modification of hygromycin A. 1. Synthesis and antibacterial activity of vinyl methyl and amide analogs.

Bioorganic & Medicinal Chemistry Letters
1992.0

Abstract

Formation of the peracetate of hygromycin A, followed by sodium borohydride reduction and oxidative cleavage, affords an aldehyde which serves as a key intermediate for preparation of vinyl methyl and amide analogs. Several analogs of each type were prepared and tested for activity against Serpulina hyodysenteriae, the causative organism of swine dysentery.

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