Synthesis and vitro antibacterial activity of hygromycin a analogs modified at the C4′ aryl position

Bioorganic & Medicinal Chemistry Letters
1993.0

Abstract

A variety of hygromycin A analogs are described which contain modifications of or replacements for the natural sugar. Antibacterial activities against SerpuZina (Treponema) hyodysenferiae, an important animal health pathogen, are mported and indicate that small lipophilic cq' substituents serve as useful sugar surrogates in the hygromycin A class.

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