Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]

Bioorganic & Medicinal Chemistry Letters
1993.0

Abstract

Coupling between brevifoliol (I) and β-lactam (2) yielded, after protecting group removal, brevifoliol 13-[N-benzoyl-(2'R,3'S)-3'-phenylisoserinate] (3). This novel taxol analogue was found to be inactive in the microtubule binding assay and had little cytotoxicity against B16 melanoma cells.

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