Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthase

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Two series of ¢g-amino phosphonic and or-amino phosphinic analogs of arginine were prepared and tested as inhibitors of nitric oxide synthase (NOS). Two of the analogs were found to possess inhibitory activity for the neuronal isoform of NOS.

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