Literature

Abstract

Conformationally restricted analogues of the endogenous NOS substrate L-arginine and the arginine based NOS inhibitors NG-methyl-L-arginine (L-NMA) and NS-iminoethyl-L-ornithine (L-NIt) were synthesized for evaluation as inhibitors of human NOS. Incorporation of a phenyl ring into the C4-C5 backbone chain provided 2-aminophenylalanine analogues which retained potent NOS inhibition. Structurally related analogues of 3-aminophenylalanine were significantly weaker inhibitors. © 1997 Elsevier Science Ltd.

DOI： 10.1016/S0960-894X(97)00309-0

Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase

Bioorganic & Medicinal Chemistry Letters 1997.0

Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthase

Bioorganic & Medicinal Chemistry Letters 1996.0

Nitroaromatic Amino Acids as Inhibitors of Neuronal Nitric Oxide Synthase

Journal of Medicinal Chemistry 1998.0

Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine

Bioorganic & Medicinal Chemistry 2011.0

l-Arginine analogs as alternate substrates for nitric oxide synthase

Bioorganic & Medicinal Chemistry Letters 2005.0

N-Phenylamidines as Selective Inhibitors of Human Neuronal Nitric Oxide Synthase: Structure−Activity Studies and Demonstration of in Vivo Activity