C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity. Oxygen-bearing substituents along the 2-carbon tether can further increase the potency of this design.

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