Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus

Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1′ substituent Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent P1′ oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1 Novel HIV-1 protease inhibitors active against multiple PI-Resistant viral strains: coadministration with indinavir Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains