P1′ oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1

P1′ oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1 HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1′ substituent Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies Novel inhibitors of HIV protease Synthesis of PotentC₂-Symmetric, Diol-Based HIV-1 Protease Inhibitors. Investigation of Thioalkyl and Thioaryl P1/P1‘ Substituents Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus