A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis inhibition while retaining good antibacterial potency.

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