Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist

Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist Biarylpyrazole Inverse Agonists at the Cannabinoid CB1 Receptor:  Importance of the C-3 Carboxamide Oxygen/Lysine3.28(192) Interaction Bioisosteric replacement of dihydropyrazole of 4S-(−)-3-(4-chlorophenyl)-N-methyl-N′-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB 1 receptor ligand antagonists Arylsulfonamides as a new class of cannabinoid CB1 receptor ligands: Identification of a lead and initial SAR studies Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists Pyrazole antagonists of the CB1 receptor with reduced brain penetration Discovery of 1,1-dioxo-1,2,6-thiadiazine-5-carboxamide derivatives as cannabinoid-like molecules with agonist and antagonist activity Novel pyrazole derivatives as neutral CB 1 antagonists with significant activity towards food intake Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1- f ][1,6]naphthyridines as CB 2 receptor antagonists/inverse agonists