Part 1: N-Alkylated glycines as potent α2δ ligands

Bioorganic & Medicinal Chemistry Letters
2011.0

Abstract

A new series of glycine-derived ligands of the α(2)δ subunit of voltage gated calcium channels is described. Several novel compounds (7) based on (6) were prepared that possessed a potency <100 nM in the α(2)δ binding assay.

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