Synthesis and in vivo evaluation of 3-substituted gababutins

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the alpha2delta calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in vivo models of pain and anxiety.

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