Synthesis and biological evaluation of novel HIV-1 protease inhibitors using tertiary amine as P2-ligands

Synthesis and biological evaluation of novel HIV-1 protease inhibitors using tertiary amine as P2-ligands Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants Novel inhibitors of HIV protease Design and biological evaluation of cinnamic and phenylpropionic amide derivatives as novel dual inhibitors of HIV-1 protease and reverse transcriptase HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol: Improved Antiviral Activity in Cells Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385