Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385

Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385 Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus Synthesis and biological evaluation of novel HIV-1 protease inhibitors using tertiary amine as P2-ligands Discovery of GS-8374, a potent human immunodeficiency virus type 1 protease inhibitor with a superior resistance profile Novel inhibitors of HIV protease Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus Design of HIV-1 Protease Inhibitors Active on Multidrug-Resistant Virus HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1′ substituent Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles