Unlike most rutaceous genera, Amyris has attracted little attention of chemists. Recently, coumarins were reported in A. simplicifolia and A. madrensis, and re-examination of the essential oil of A. balsamifera yielded several sesquiterpenes. We now describe two nicotinamides from the benzene extract of the Jamaican variety of Amyris plumieri, a plant reclassified as Rutaceae from Burseraceae. Compound I (C₁₉H₂₀N₂O₂) was characterized as a C-substituted chromene nicotinamide via UV, IR, ¹H NMR, mass spectral data, hydrogenation to dihydroderivative II, and biogenetic synthesis. Compound III (C₁₆H₁₈N₂O₃) was identified as a trans-styryl nicotinamide based on spectral analysis, hydrogenation to IV, and ozonolysis. The presence of chromene and amide moieties, along with the masked nicotinamide O-dimethylallyl halfordinol (V, an oxazole found only in Rutaceae), supports the rutaceous classification of A. plumieri. Compounds I and III are the first reported unmasked nicotinamides in Rutaceae.