We have isolated from the tubers of Aconitum karakolicum collected in the Kirghiz SSR, Kungei Alatau range, songorine, napelline, a base with mp 159-160°C, and the new alkaloids karakoline and a base with mp 222-224°C. The results of a study of the chemical reactions and spectral characteristics of karakoline have shown that it consists of a lycoctonine skeleton with N-ethyl and C4-methyl groups, hydroxyls at C1, C8, and C10 and a methoxy group at C15. © 1975 Plenum Publishing Corporation.