Thalidomide analogs and PDE4 inhibition

Thalidomide analogs and PDE4 inhibition Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes α-Fluoro-substituted thalidomide analogues Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor Novel Selective PDE4 Inhibitors. 3. In Vivo Antiinflammatory Activity of a New Series of N-Substituted cis-Tetra- and cis-Hexahydrophthalazinones Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I Identification of a potent new chemotype for the selective inhibition of PDE4