Optimising inhibitors of Trypanothione reductase using solid-phase chemistry

Optimising inhibitors of Trypanothione reductase using solid-phase chemistry The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial Drugs High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase Inhibitors ofTrypanosoma cruziTrypanothione Reductase Revealed by Virtual Screening and Parallel Synthesis Inhibition of Trypanosoma cruzi Trypanothione Reductase by Acridines:  Kinetic Studies and Structure−Activity Relationships Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity Synthesis and in vitro antikinetoplastid activity of polyamine–hydroxybenzotriazole conjugates Pyridazino-pyrrolo-quinoxalinium salts as highly potent and selective leishmanicidal agents targeting trypanothione reductase