The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains

The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent P1′ oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1 Novel HIV-1 protease inhibitors active against multiple PI-Resistant viral strains: coadministration with indinavir Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1′ substituent Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains Novel inhibitors of HIV protease Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-Resistant viral strains Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies