Synthesis and biological evaluation of conformationally restricted gabapentin analogues

Synthesis and biological evaluation of conformationally restricted gabapentin analogues Investigation into the preferred conformation of gabapentin for interaction with its binding site on the α2δ subunit of a calcium channel Synthesis and in vivo evaluation of 3-substituted gababutins Synthesis and in vivo evaluation of 3,4-disubstituted gababutins Carboxylate bioisosteres of gabapentin N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the α2δ subunit of voltage gated calcium channels Carboxylate bioisosteres of pregabalin Structure–activity relationships of α-amino acid ligands for the α2δ subunit of voltage-gated calcium channels Novel Cyclopropyl β-Amino Acid Analogues of Pregabalin and Gabapentin That Target the α₂-δ Protein Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury