Combinatorial diversification of indinavir: in vivo mixture dosing of an HIV protease inhibitor library

Combinatorial diversification of indinavir: in vivo mixture dosing of an HIV protease inhibitor library A Combinatorial Library of Indinavir Analogues and Its In Vitro and In Vivo Studies Novel HIV-1 protease inhibitors active against multiple PI-Resistant viral strains: coadministration with indinavir Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent Novel inhibitors of HIV protease Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1′ substituent Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-Resistant viral strains