A Combinatorial Library of Indinavir Analogues and Its In Vitro and In Vivo Studies

A Combinatorial Library of Indinavir Analogues and Its In Vitro and In Vivo Studies Combinatorial diversification of indinavir: in vivo mixture dosing of an HIV protease inhibitor library Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-Resistant viral strains The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains Novel inhibitors of HIV protease Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2 Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains Novel HIV-1 protease inhibitors active against multiple PI-Resistant viral strains: coadministration with indinavir